Click here to become a Doterra wholesale member and enjoy up to 30% off doterra oil prices. You will need my doTerra ID for the registration, it is 5296742. The image below shows where you enter it.
find a few of my favorite combos for diffusing by clicking on the direct links below;
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Chai Blend - Coriander , Sweet Fennel , Cardamom, Cinnamon, Clove, Black Pepper, Ginger Warm, Floral, Comforting, Relaxing - Geranium and Sandalwood Clean, energizing, clarity- Peppermint and Lemongrass Grounding, calming, soothing - Cypress and Frankinsence 
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50 RESEARCH ARTICLES ON ESSENTIAL OILS LINKED BELOW
In general, many different oils, Lavender being one, have been found to temporarily relax the sympathetic (flight or fright) part of the nervous system, temporarily relieving or decreasing symptoms of mild anxiety, stress/tension, mild depressive symptoms. Many others are anti-inflamatory like Frankinsence. Some are mildly antibacterial like Tea Tree oil and can be used in home made face washes, deodorants, soaps, lotions.
At minimum, the firsthand experience of diffusing any essential oil mix you enjoy is wonderful and makes you feel good. If you have any specific questions about bringing essential oils into your life, email Dr Starsiak by Clicking HERE.
Female Hormones
https://pubmed.ncbi.nlm.nih.gov/24802524/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721455/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428160/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238350/
Essential Oil Hormone Summit Webinar Recording (50 mins) Dr Mariza Snyder http://hwcdn.libsyn.com/p/0/9/d/09df43dcf9988939/EO-Hormone-Summit_Bridgit_Danner.mp3?c_id=24014243&cs_id=24014243&expiration=1594307432&hwt=25675d06bbca2d02262f01e2a98859ac
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788221/
ClaryCalm blend includes most all the oils mentioned https://media.doterra.com/us/en/pips/doterra-clarycalm-essential-oil-blend.pdf
Menopause
https://pubmed.ncbi.nlm.nih.gov/28326753/
https://www.doterra.com/US/en/brochures-magazines-living-winter-2013-2014-womens-hormonal-health
https://www.medicalnewstoday.com/articles/317918
https://media.doterra.com/us/en/pips/doterra-phytoestrogen-lifetime-complex.pdf
Male Hormones
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778952/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316093/
https://pubmed.ncbi.nlm.nih.gov/16822218/ (the purist source of Pumpkin Seed oil is https://www.seedoilcompany.com/)
Hypothyroidism
An argument for Black Pepper and Cinnamon essential oils, in addition to the use LifeLong Vitality supplementation https://jme.bioscientifica.com/view/journals/jme/62/1/JME-18-0081.xml (https://media.doterra.com/us/en/brochures/lifelong-vitality.pdf)
https://www.degruyter.com/view/journals/jcim/17/1/article-20180229.xml
Diabetes
Melissa oil possibilities https://pubmed.ncbi.nlm.nih.gov/28911435/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891552/
High Cholesterol
https://www.tandfonline.com/doi/full/10.1080/19390211.2017.1331943
Anxiety/Depression - Adaptiv Calming Bland
https://www.doterra.com/US/en/blog/science-research-news-science-behind-adaptive-calming-blend
https://www.doterra.com/US/en/adaptiv-oil-capsules
Why the oils included in Adaptiv?
https://www.doterra.com/US/en/blog/science-research-news-linalool-gaba-receptors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099651/
https://www.doterra.com/US/en/education/pe/adaptiv-oil-capsules
https://media.doterra.com/us/en/pips/doterra-adaptiv-essential-oil-blend-capsules.pdf
https://www.doterra.com/US/en/adaptiv-oil
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441155/
https://www.ncbi.nlm.nih.gov/pubmed/25024731
https://www.ncbi.nlm.nih.gov/pubmed/21410035
https://www.ncbi.nlm.nih.gov/pubmed/22086772
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034497/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700080/
https://www.ncbi.nlm.nih.gov/pubmed/17291597
https://www.ncbi.nlm.nih.gov/pubmed/24050594
https://www.ncbi.nlm.nih.gov/pubmed/15764002 https://www.ncbi.nlm.nih.gov/pubmed/24238073
https://www.ncbi.nlm.nih.gov/pubmed/22612017
http://hms.gmu.ac.ir/browse.php?a_id=277&sid=1&slc_lang=en https://www.ncbi.nlm.nih.gov/pubmed/16095639
doTERRA Anchor Chemistry
S. Dayawansa, K. Umeno, H. Takakura, E. Hori, E. Tabuchi, Y. Nagashima, H. Oosu, Y. Yada, T. Suzuki, T. Ono, and H. Nishijo, “Autonomic responses during inhalation of natural fragrance of ‘Cedrol’ in humans,” Auton. Neurosci., vol. 108, no. 1–2, pp. 79–86, Oct. 2003. https://www.ncbi.nlm.nih.gov/pubmed/28634728
Y. Yada, H. Sadachi, Y. Nagashima, and T. Suzuki, “Overseas survey of the effect of cedrol on the autonomic nervous system in three countries,” J. Physiol. Anthropol., vol. 26, no. 3, pp. 349–354, 2007. https://www.ncbi.nlm.nih.gov/pubmed/17641454
Milanos S, Elsharif SA, Janzen D et al. Metabolic Products of Linalool and Modulation of GABAA receptors. Front Chem. 2017 Jun 21;5:46. doi: 10.3389/fchem.2017.00046. eCollection 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478857/
D. Nord and J. Belew, “Effectiveness of the essential oils lavender and ginger in promoting children’s comfort in a perianesthesia setting,” J. Perianesthesia Nurs. Off. J. Am. Soc. PeriAnesthesia Nurses Am. Soc. PeriAnesthesia Nurses, vol. 24, no. 5, pp. 307–312, Oct. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19853815
R. McCaffrey, D. J. Thomas, and A. O. Kinzelman, “The effects of lavender and rosemary essential oils on test-taking anxiety among graduate nursing students,” Holist. Nurs. Pract., vol. 23, no. 2, pp. 88–93, Apr. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19258850
Zhu R, Liu H, Liu C et al. Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacol Res. 2017 Aug;122:78-89. doi: 10.1016/j.phrs.2017.05.019. https://www.ncbi.nlm.nih.gov/pubmed/28559210
doTERRA Align Chemistry
Soto-Vásquez MR, Alvarado-García PA. Aromatherapy with two essential oils from Satureja genre and mindfulness meditation to reduce anxiety in humans. J Tradit Complement Med. 2016;7(1):121-125. http://www.sciencedirect.com/science/article/pii/S2225411016300438
Singer, MS. Analysis of the molecular basis for octanal interactions in the expressed rat 17 olfactory receptor. Chem Senses 25:155-165, 2000. https://www.ncbi.nlm.nih.gov/pubmed/10781022
D. P. de Sousa, P. de Almeida Soares Hocayen, L. N. Andrade, and R. Andreatini, “A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models,” Mol. Basel Switz., vol. 20, no. 10, pp. 18620–18660, 2015. https://www.ncbi.nlm.nih.gov/pubmed/26473822
L. Rombolà, M. T. Corasaniti, D. Rotiroti, C. Tassorelli, S. Sakurada, G. Bagetta, and L. A. Morrone, “Effects of systemic administration of the essential oil of bergamot (BEO) on gross behaviour and EEG power spectra recorded from the rat hippocampus and cerebral cortex,” Funct. Neurol., vol. 24, no. 2, pp. 107–112, Jun. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19775539
D. Amantea, V. Fratto, S. Maida, D. Rotiroti, S. Ragusa, G. Nappi, G. Bagetta, and M. T. Corasaniti, “Chapter 27 Prevention of Glutamate Accumulation and Upregulation of Phospho‐Akt may Account for Neuroprotection Afforded by Bergamot Essential Oil against Brain Injury Induced by Focal Cerebral Ischemia in Rat,” in International Review of Neurobiology, vol. 85, Elsevier, 2009, pp. 389–405. https://www.ncbi.nlm.nih.gov/pubmed/19607983
T. Sakurada, H. Mizoguchi, H. Kuwahata, S. Katsuyama, T. Komatsu, L. A. Morrone, M. T. Corasaniti, G. Bagetta, and S. Sakurada, “Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism,” Pharmacol. Biochem. Behav., vol. 97, no. 3, pp. 436–443, Jan. 2011. https://www.ncbi.nlm.nih.gov/pubmed/20932858
M. T. Corasaniti, J. Maiuolo, S. Maida, V. Fratto, M. Navarra, R. Russo, D. Amantea, L. A. Morrone, and G. Bagetta, “Cell signaling pathways in the mechanisms of neuroprotection
afforded by bergamot essential oil against NMDA-induced cell death in vitro,” Br. J. Pharmacol., vol. 151, no. 4, pp. 518–529, Jun. 2007. https://www.ncbi.nlm.nih.gov/pubmed/17401440
H. Kuwahata, T. Komatsu, S. Katsuyama, M. T. Corasaniti, G. Bagetta, S. Sakurada, T. Sakurada, and K. Takahama, “Peripherally injected linalool and bergamot essential oil attenuate mechanical allodynia via inhibiting spinal ERK phosphorylation,” Pharmacol. Biochem. Behav., vol. 103, no. 4, pp. 735–741, Feb. 2013. https://www.ncbi.nlm.nih.gov/pubmed/23159543
R. Tundis, M. R. Loizzo, M. Bonesi, F. Menichini, V. Mastellone, C. Colica, and F. Menichini, “Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia Swingle, C. aurantium L., and C. bergamia Risso and Poit. peel essential oils,” J. Food Sci., vol. 77, no. 1, pp. H40-46, Jan. 2012. https://www.ncbi.nlm.nih.gov/pubmed/22260108
S. Darvesh, D. A. Hopkins, and C. Geula, “Neurobiology of butyrylcholinesterase,” Nat. Rev. Neurosci., vol. 4, no. 2, pp. 131–138, Feb. 2003. https://www.nature.com/articles/nrn1035
L. A. Morrone, L. Rombolà, C. Pelle, M. T. Corasaniti, S. Zappettini, P. Paudice, G. Bonanno, and G. Bagetta, “The essential oil of bergamot enhances the levels of amino acid neurotransmitters in the hippocampus of rat: Implication of monoterpene hydrocarbons,” Pharmacol. Res., vol. 55, no. 4, pp. 255–262, Apr. 2007. https://www.ncbi.nlm.nih.gov/pubmed/17196823
K.-M. Chang and C.-W. Shen, “Aromatherapy benefits autonomic nervous system regulation for elementary school faculty in taiwan,” Evid.-Based Complement. Altern. Med. ECAM, vol. 2011, p. 946537, 2011. https://www.hindawi.com/journals/ecam/2011/946537/
C.-H. Ni, W.-H. Hou, C.-C. Kao, M.-L. Chang, L.-F. Yu, C.-C. Wu, and C. Chen, “The Anxiolytic Effect of Aromatherapy on Patients Awaiting Ambulatory Surgery: A Randomized Controlled Trial,” Evid. Based Complement. Alternat. Med., vol. 2013, pp. 1–5, 2013. https://www.ncbi.nlm.nih.gov/pubmed/24454517
E. Watanabe, K. Kuchta, H. Rauwald, T. Kamei, and J. Imanishi, “Mood enhancement by bergamot (Citrus bergamia (Risso) Wright & Arn.) volatile oil vapor with regards to personality and lifestyle related changes in salivary cortisol levels: A randomized cross-over trial,” Planta Med., vol. 79, no. 13, Aug. 2013. https://www.ncbi.nlm.nih.gov/pubmed/25824404
K. Lemon, “An assessment of treating depression and anxiety with aromatherapy,” Int. J. Aromather., vol. 14, no. 2, pp. 63–69, 2004. https://eurekamag.com/research/004/035/004035535.php
S.-H. Liu, T.-H. Lin, and K.-M. Chang, “The Physical Effects of Aromatherapy in Alleviating Work-Related Stress on Elementary School Teachers in Taiwan,” Evid. Based Complement. Alternat. Med., vol. 2013, pp. 1–7, 2013. https://www.researchgate.net/publication/258524002_The_Physical_Effects_of_Aromatherapy_in_Alleviating_Work-Related_Stress_on_Elementary_School_Teachers_in_Taiwan
E. Watanabe, K. Kuchta, M. Kimura, H. W. Rauwald, T. Kamei, and J. Imanishi, “Effects of bergamot (Citrus bergamia (Risso) Wright & Arn.) essential oil aromatherapy on mood states, https://www.ncbi.nlm.nih.gov/pubmed/25824404
Muhammad Nadeem, Faqir Muhammad Anjum, Muhammad Issa Khan, Saima Tehseen, Ahmed El ‐ Ghorab, and Javed Iqbal Sultan, “Nutritional and medicinal aspects of coriander (Coriandrum sativum L.),” Br. Food J., vol. 115, no. 5, pp. 743–755, May 2013. http://www.emeraldinsight.com/doi/abs/10.1108/00070701311331526?journalCode=bfj
“Plant Care Guides :: National Gardening Association.” [Online]. Available: http://www.garden.org/plantguide/?q=show&id=3362 . [Accessed: 17-Jul-2015].
O. Cioanca, L. Hritcu, M. Mihasan, A. Trifan, and M. Hancianu, “Inhalation of coriander volatile oil increased anxiolytic-antidepressant-like behaviors and decreased oxidative status in beta-amyloid (1-42) rat model of Alzheimer’s disease,” Physiol. Behav., vol. 131,
pp. 68–74, May 2014. https://www.ncbi.nlm.nih.gov/pubmed/24747275
I.-H. Kim, C. Kim, K. Seong, M.-H. Hur, H. M. Lim, and M. S. Lee, “Essential Oil Inhalation on Blood Pressure and Salivary Cortisol Levels in Prehypertensive and Hypertensive Subjects,” Evid.-Based Complement. Altern. Med. ECAM, vol. 2012, 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521421/
M.-C. Ou, Y.-F. Lee, C.-C. Li, and S.-K. Wu, “The effectiveness of essential oils for patients with neck pain: a randomized controlled study,” J. Altern. Complement. Med. N. Y. N, vol. 20, no. 10, pp. 771– 779, Oct. 2014. https://www.ncbi.nlm.nih.gov/pubmed/25192562
T. Umezu, “Evaluation of the Effects of Plant-derived Essential Oils on Central Nervous System Function Using Discrete Shuttle-type Conditioned Avoidance Response in Mice: ESSENTIAL OILS AND AVOIDANCE RESPONSE,” Phytother. Res., vol. 26, no. 6, pp. 884–891, Jun. 2012. https://www.ncbi.nlm.nih.gov/pubmed/22086772
K. Kuroda, N. Inoue, Y. Ito, K. Kubota, A. Sugimoto, T. Kakuda, and T. Fushiki, “Sedative effects of the jasmine tea odor and (R)-(-)-linalool, one of its major odor components, on autonomic nerve activity and mood states,” Eur. J. Appl. Physiol., vol. 95, no. 2–3, pp. 107–114, Oct. 2005. https://www.ncbi.nlm.nih.gov/pubmed/15976995
doTERRA Arise Chemistry
Goepfert M, Liebl P, Herth N et al. Aroma oil therapy in palliative care: a pilot study with physiological parameters in conscious as well as unconscious patients. J Cancer Res Clin Oncol. (2017) Jun 20. doi: 10.1007/s00432-017-2460-0 https://www.ncbi.nlm.nih.gov/pubmed/28634728
Heuberger E, Hongratanaworakit T, Böhm C, Weber R, Buchbauer G. Effects of chiral fragrances on human autonomic nervous system parameters and self-evaluation. Chem Senses. 2001 Mar;26(3):281-92. https://www.ncbi.nlm.nih.gov/pubmed/11287388
Yang H, Woo J, Pae AN et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539. Epub 2016 Aug 29. https://www.ncbi.nlm.nih.gov/pubmed/27573669
Matsubara E, Fukagawa M, Okamoto T et al. (-)-Bornyl acetate induces autonomic relaxation and reduces arousal level after visual display terminal work without any influences of task performance in low-dose condition. Biomed Res. 2011 Apr;32(2):151-7 https://www.ncbi.nlm.nih.gov/pubmed/21551951
Matsubara E, Fukagawa M, Okamoto T et al. The essential oil of Abies sibirica (Pinaceae) reduces arousal levels after visual display terminal work. Flavour Frag J. 2011;26(3):204-210. https://www.researchgate.net/publication/230089859_The_essential_oil_of_Abies_sibirica_Pinaceae_reduces_arousal_levels_after_visual_display_terminal_work
Guzmán-Gutiérrez SL, Bonilla-Jaime H, Gómez-Cansino R et al. Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway. Life Sci. 2015 May 1;128:24-9. doi: 10.1016/j.lfs.2015.02.021. https://www.ncbi.nlm.nih.gov/pubmed/25771248
Chemistry of Siberian Fir Oil
Boyd EM, Sheppard EP. Nutmeg Oil and Camphene as Inhaled Expectorants. Arch Otolaryngol. 1970;92(4):372-378. doi:10.1001/archotol.1970.04310040060011 https://books.google.com/books?id=rGQps9fQX1YC&pg=PA355&lpg=PA355&dq=Nutmeg+Oil+and+Camphene+as+Inhaled+Expectorants&source=bl&ots=BpYoQFgdia&sig=3dE-NHkfhFmGWbSTNDx_KJi33TA&hl=en&sa=X&ved=0ahUKEwjM2tjs177XAhVFPCYKHWJnA04Q6AEITDAJ#v=onepage&q=Nutmeg%20Oil%20and%20Camphene%20as%20Inhaled%20Expectorants&f=false
Kim SH, Lee SY, Hong CY et al. Whitening and antioxidant activities of bornyl acetate and nezukol fractionated from Cryptomeria japonica essential oil. Int J Cosmet Sci. 2013
Oct;35(5):484-90. doi: 10.1111/ics.12069. Epub 2013 Jul 6. https://www.ncbi.nlm.nih.gov/pubmed/23714012
Yang H, Woo J, Pae AN et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539. Epub 2016 Aug 29. https://www.ncbi.nlm.nih.gov/pubmed/27573669
Sleep: Lavender & L-Theanine
Chong Y, Fryar C, Gu Q. Prescription sleep aid use among adults: United States, 2005-2010. NCHS Data Brief. August 2013; 127. Retrieved from: http://www.cdc.gov/nchs/data/databriefs/db127.pdf
Afshar M, et al. Lavender fragrance essential oil and the quality of sleep in postpartum women. Iran Red Crescent Med J. 2015; 17(4):e25880.
Lee S. Effects of aroma inhalation on fatigue and sleep quality of postpartum mothers. Women Heath Nurs. 2004; 10(3):235-243. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443384/
Hirokawa K, Nishimoto T, Taniguchi T. The effects of lavender aroma on sleep quality in healthy Japanese students. Percept Mot Skills. 2012; 114(1):111-122. https://www.ncbi.nlm.nih.gov/pubmed/22582680
Field T, et al. Lavender bath oil reduces stress and crying and enhances sleep in very young infants. Early Human Development. 2008; 84(6):339-401. https://www.ncbi.nlm.nih.gov/pubmed/18053656
Smith A, Halcon L, Savik K, Reis R. Effect of lavender and sleep hygiene on self-reported sleep issues: A randomized controlled trial. J Am Coll Nutri. 2015; 34(5):436-47. https://www.ncbi.nlm.nih.gov/pubmed/26133206
Schuwald A, Noldner M, Wilmes T, Klugbauer N, Leuner K, Muller W. Lavender oil-potent anxiolytic properties via modulation voltage dependent calcium channels. PLoS One. 2013; 8(4):e59998. https://www.ncbi.nlm.nih.gov/pubmed/23637742
Dimpfel W, Pischel I, Lehnfeld R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity in volunteers. Eur. J. Med. Res. 2004; 9(9):423-431. https://www.ncbi.nlm.nih.gov/pubmed/15546807
Ghelardini C, Galeotti N, Salvatore G, Mazzanti G. Local anasthetic activity of the essential oil of Lavandula angustifolia. Planta Med.1999; 65(8):700-703. https://www.ncbi.nlm.nih.gov/pubmed/10630108
Barrett J, Tracy D, Giaroli G. To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2013; 23(10):640-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870602/
Lyon M, Kapoor M, Juneja L. The effects of L-theanine on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011; 16(4):348-54. https://www.ncbi.nlm.nih.gov/pubmed/22214254
Ota M, et al. Effect of L-theanine on glutamatergic functions in patients with schizophrenia. Acta Neuropsychiatr. 2015; 27(5):291-6.
Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T. Effects of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res. 1998; 23(5):667-73. https://www.ncbi.nlm.nih.gov/pubmed/25896423
Lavender Oil and Serotonin
López, V., Nielsen, B., Solas, M., Ramírez, M. J., & Jäger, A. K. (2017). Exploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System Targets. Frontiers in Pharmacology, 8. doi:10.3389/fphar.2017.00280
In general, many different oils, Lavender being one, have been found to temporarily relax the sympathetic (flight or fright) part of the nervous system, temporarily relieving or decreasing symptoms of mild anxiety, stress/tension, mild depressive symptoms. Many others are anti-inflamatory like Frankinsence. Some are mildly antibacterial like Tea Tree oil and can be used in home made face washes, deodorants, soaps, lotions.
At minimum, the firsthand experience of diffusing any essential oil mix you enjoy is wonderful and makes you feel good. If you have any specific questions about bringing essential oils into your life, email Dr Starsiak by Clicking HERE.
Female Hormones
https://pubmed.ncbi.nlm.nih.gov/24802524/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721455/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428160/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238350/
Essential Oil Hormone Summit Webinar Recording (50 mins) Dr Mariza Snyder http://hwcdn.libsyn.com/p/0/9/d/09df43dcf9988939/EO-Hormone-Summit_Bridgit_Danner.mp3?c_id=24014243&cs_id=24014243&expiration=1594307432&hwt=25675d06bbca2d02262f01e2a98859ac
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788221/
ClaryCalm blend includes most all the oils mentioned https://media.doterra.com/us/en/pips/doterra-clarycalm-essential-oil-blend.pdf
Menopause
https://pubmed.ncbi.nlm.nih.gov/28326753/
https://www.doterra.com/US/en/brochures-magazines-living-winter-2013-2014-womens-hormonal-health
https://www.medicalnewstoday.com/articles/317918
https://media.doterra.com/us/en/pips/doterra-phytoestrogen-lifetime-complex.pdf
Male Hormones
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778952/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316093/
https://pubmed.ncbi.nlm.nih.gov/16822218/ (the purist source of Pumpkin Seed oil is https://www.seedoilcompany.com/)
Hypothyroidism
An argument for Black Pepper and Cinnamon essential oils, in addition to the use LifeLong Vitality supplementation https://jme.bioscientifica.com/view/journals/jme/62/1/JME-18-0081.xml (https://media.doterra.com/us/en/brochures/lifelong-vitality.pdf)
https://www.degruyter.com/view/journals/jcim/17/1/article-20180229.xml
Diabetes
Melissa oil possibilities https://pubmed.ncbi.nlm.nih.gov/28911435/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891552/
High Cholesterol
https://www.tandfonline.com/doi/full/10.1080/19390211.2017.1331943
Anxiety/Depression - Adaptiv Calming Bland
https://www.doterra.com/US/en/blog/science-research-news-science-behind-adaptive-calming-blend
https://www.doterra.com/US/en/adaptiv-oil-capsules
Why the oils included in Adaptiv?
https://www.doterra.com/US/en/blog/science-research-news-linalool-gaba-receptors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099651/
https://www.doterra.com/US/en/education/pe/adaptiv-oil-capsules
https://media.doterra.com/us/en/pips/doterra-adaptiv-essential-oil-blend-capsules.pdf
https://www.doterra.com/US/en/adaptiv-oil
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441155/
https://www.ncbi.nlm.nih.gov/pubmed/25024731
https://www.ncbi.nlm.nih.gov/pubmed/21410035
https://www.ncbi.nlm.nih.gov/pubmed/22086772
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034497/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700080/
https://www.ncbi.nlm.nih.gov/pubmed/17291597
https://www.ncbi.nlm.nih.gov/pubmed/24050594
https://www.ncbi.nlm.nih.gov/pubmed/15764002 https://www.ncbi.nlm.nih.gov/pubmed/24238073
https://www.ncbi.nlm.nih.gov/pubmed/22612017
http://hms.gmu.ac.ir/browse.php?a_id=277&sid=1&slc_lang=en https://www.ncbi.nlm.nih.gov/pubmed/16095639
doTERRA Anchor Chemistry
S. Dayawansa, K. Umeno, H. Takakura, E. Hori, E. Tabuchi, Y. Nagashima, H. Oosu, Y. Yada, T. Suzuki, T. Ono, and H. Nishijo, “Autonomic responses during inhalation of natural fragrance of ‘Cedrol’ in humans,” Auton. Neurosci., vol. 108, no. 1–2, pp. 79–86, Oct. 2003. https://www.ncbi.nlm.nih.gov/pubmed/28634728
Y. Yada, H. Sadachi, Y. Nagashima, and T. Suzuki, “Overseas survey of the effect of cedrol on the autonomic nervous system in three countries,” J. Physiol. Anthropol., vol. 26, no. 3, pp. 349–354, 2007. https://www.ncbi.nlm.nih.gov/pubmed/17641454
Milanos S, Elsharif SA, Janzen D et al. Metabolic Products of Linalool and Modulation of GABAA receptors. Front Chem. 2017 Jun 21;5:46. doi: 10.3389/fchem.2017.00046. eCollection 2017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478857/
D. Nord and J. Belew, “Effectiveness of the essential oils lavender and ginger in promoting children’s comfort in a perianesthesia setting,” J. Perianesthesia Nurs. Off. J. Am. Soc. PeriAnesthesia Nurses Am. Soc. PeriAnesthesia Nurses, vol. 24, no. 5, pp. 307–312, Oct. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19853815
R. McCaffrey, D. J. Thomas, and A. O. Kinzelman, “The effects of lavender and rosemary essential oils on test-taking anxiety among graduate nursing students,” Holist. Nurs. Pract., vol. 23, no. 2, pp. 88–93, Apr. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19258850
Zhu R, Liu H, Liu C et al. Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacol Res. 2017 Aug;122:78-89. doi: 10.1016/j.phrs.2017.05.019. https://www.ncbi.nlm.nih.gov/pubmed/28559210
doTERRA Align Chemistry
Soto-Vásquez MR, Alvarado-García PA. Aromatherapy with two essential oils from Satureja genre and mindfulness meditation to reduce anxiety in humans. J Tradit Complement Med. 2016;7(1):121-125. http://www.sciencedirect.com/science/article/pii/S2225411016300438
Singer, MS. Analysis of the molecular basis for octanal interactions in the expressed rat 17 olfactory receptor. Chem Senses 25:155-165, 2000. https://www.ncbi.nlm.nih.gov/pubmed/10781022
D. P. de Sousa, P. de Almeida Soares Hocayen, L. N. Andrade, and R. Andreatini, “A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models,” Mol. Basel Switz., vol. 20, no. 10, pp. 18620–18660, 2015. https://www.ncbi.nlm.nih.gov/pubmed/26473822
L. Rombolà, M. T. Corasaniti, D. Rotiroti, C. Tassorelli, S. Sakurada, G. Bagetta, and L. A. Morrone, “Effects of systemic administration of the essential oil of bergamot (BEO) on gross behaviour and EEG power spectra recorded from the rat hippocampus and cerebral cortex,” Funct. Neurol., vol. 24, no. 2, pp. 107–112, Jun. 2009. https://www.ncbi.nlm.nih.gov/pubmed/19775539
D. Amantea, V. Fratto, S. Maida, D. Rotiroti, S. Ragusa, G. Nappi, G. Bagetta, and M. T. Corasaniti, “Chapter 27 Prevention of Glutamate Accumulation and Upregulation of Phospho‐Akt may Account for Neuroprotection Afforded by Bergamot Essential Oil against Brain Injury Induced by Focal Cerebral Ischemia in Rat,” in International Review of Neurobiology, vol. 85, Elsevier, 2009, pp. 389–405. https://www.ncbi.nlm.nih.gov/pubmed/19607983
T. Sakurada, H. Mizoguchi, H. Kuwahata, S. Katsuyama, T. Komatsu, L. A. Morrone, M. T. Corasaniti, G. Bagetta, and S. Sakurada, “Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism,” Pharmacol. Biochem. Behav., vol. 97, no. 3, pp. 436–443, Jan. 2011. https://www.ncbi.nlm.nih.gov/pubmed/20932858
M. T. Corasaniti, J. Maiuolo, S. Maida, V. Fratto, M. Navarra, R. Russo, D. Amantea, L. A. Morrone, and G. Bagetta, “Cell signaling pathways in the mechanisms of neuroprotection
afforded by bergamot essential oil against NMDA-induced cell death in vitro,” Br. J. Pharmacol., vol. 151, no. 4, pp. 518–529, Jun. 2007. https://www.ncbi.nlm.nih.gov/pubmed/17401440
H. Kuwahata, T. Komatsu, S. Katsuyama, M. T. Corasaniti, G. Bagetta, S. Sakurada, T. Sakurada, and K. Takahama, “Peripherally injected linalool and bergamot essential oil attenuate mechanical allodynia via inhibiting spinal ERK phosphorylation,” Pharmacol. Biochem. Behav., vol. 103, no. 4, pp. 735–741, Feb. 2013. https://www.ncbi.nlm.nih.gov/pubmed/23159543
R. Tundis, M. R. Loizzo, M. Bonesi, F. Menichini, V. Mastellone, C. Colica, and F. Menichini, “Comparative study on the antioxidant capacity and cholinesterase inhibitory activity of Citrus aurantifolia Swingle, C. aurantium L., and C. bergamia Risso and Poit. peel essential oils,” J. Food Sci., vol. 77, no. 1, pp. H40-46, Jan. 2012. https://www.ncbi.nlm.nih.gov/pubmed/22260108
S. Darvesh, D. A. Hopkins, and C. Geula, “Neurobiology of butyrylcholinesterase,” Nat. Rev. Neurosci., vol. 4, no. 2, pp. 131–138, Feb. 2003. https://www.nature.com/articles/nrn1035
L. A. Morrone, L. Rombolà, C. Pelle, M. T. Corasaniti, S. Zappettini, P. Paudice, G. Bonanno, and G. Bagetta, “The essential oil of bergamot enhances the levels of amino acid neurotransmitters in the hippocampus of rat: Implication of monoterpene hydrocarbons,” Pharmacol. Res., vol. 55, no. 4, pp. 255–262, Apr. 2007. https://www.ncbi.nlm.nih.gov/pubmed/17196823
K.-M. Chang and C.-W. Shen, “Aromatherapy benefits autonomic nervous system regulation for elementary school faculty in taiwan,” Evid.-Based Complement. Altern. Med. ECAM, vol. 2011, p. 946537, 2011. https://www.hindawi.com/journals/ecam/2011/946537/
C.-H. Ni, W.-H. Hou, C.-C. Kao, M.-L. Chang, L.-F. Yu, C.-C. Wu, and C. Chen, “The Anxiolytic Effect of Aromatherapy on Patients Awaiting Ambulatory Surgery: A Randomized Controlled Trial,” Evid. Based Complement. Alternat. Med., vol. 2013, pp. 1–5, 2013. https://www.ncbi.nlm.nih.gov/pubmed/24454517
E. Watanabe, K. Kuchta, H. Rauwald, T. Kamei, and J. Imanishi, “Mood enhancement by bergamot (Citrus bergamia (Risso) Wright & Arn.) volatile oil vapor with regards to personality and lifestyle related changes in salivary cortisol levels: A randomized cross-over trial,” Planta Med., vol. 79, no. 13, Aug. 2013. https://www.ncbi.nlm.nih.gov/pubmed/25824404
K. Lemon, “An assessment of treating depression and anxiety with aromatherapy,” Int. J. Aromather., vol. 14, no. 2, pp. 63–69, 2004. https://eurekamag.com/research/004/035/004035535.php
S.-H. Liu, T.-H. Lin, and K.-M. Chang, “The Physical Effects of Aromatherapy in Alleviating Work-Related Stress on Elementary School Teachers in Taiwan,” Evid. Based Complement. Alternat. Med., vol. 2013, pp. 1–7, 2013. https://www.researchgate.net/publication/258524002_The_Physical_Effects_of_Aromatherapy_in_Alleviating_Work-Related_Stress_on_Elementary_School_Teachers_in_Taiwan
E. Watanabe, K. Kuchta, M. Kimura, H. W. Rauwald, T. Kamei, and J. Imanishi, “Effects of bergamot (Citrus bergamia (Risso) Wright & Arn.) essential oil aromatherapy on mood states, https://www.ncbi.nlm.nih.gov/pubmed/25824404
Muhammad Nadeem, Faqir Muhammad Anjum, Muhammad Issa Khan, Saima Tehseen, Ahmed El ‐ Ghorab, and Javed Iqbal Sultan, “Nutritional and medicinal aspects of coriander (Coriandrum sativum L.),” Br. Food J., vol. 115, no. 5, pp. 743–755, May 2013. http://www.emeraldinsight.com/doi/abs/10.1108/00070701311331526?journalCode=bfj
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O. Cioanca, L. Hritcu, M. Mihasan, A. Trifan, and M. Hancianu, “Inhalation of coriander volatile oil increased anxiolytic-antidepressant-like behaviors and decreased oxidative status in beta-amyloid (1-42) rat model of Alzheimer’s disease,” Physiol. Behav., vol. 131,
pp. 68–74, May 2014. https://www.ncbi.nlm.nih.gov/pubmed/24747275
I.-H. Kim, C. Kim, K. Seong, M.-H. Hur, H. M. Lim, and M. S. Lee, “Essential Oil Inhalation on Blood Pressure and Salivary Cortisol Levels in Prehypertensive and Hypertensive Subjects,” Evid.-Based Complement. Altern. Med. ECAM, vol. 2012, 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521421/
M.-C. Ou, Y.-F. Lee, C.-C. Li, and S.-K. Wu, “The effectiveness of essential oils for patients with neck pain: a randomized controlled study,” J. Altern. Complement. Med. N. Y. N, vol. 20, no. 10, pp. 771– 779, Oct. 2014. https://www.ncbi.nlm.nih.gov/pubmed/25192562
T. Umezu, “Evaluation of the Effects of Plant-derived Essential Oils on Central Nervous System Function Using Discrete Shuttle-type Conditioned Avoidance Response in Mice: ESSENTIAL OILS AND AVOIDANCE RESPONSE,” Phytother. Res., vol. 26, no. 6, pp. 884–891, Jun. 2012. https://www.ncbi.nlm.nih.gov/pubmed/22086772
K. Kuroda, N. Inoue, Y. Ito, K. Kubota, A. Sugimoto, T. Kakuda, and T. Fushiki, “Sedative effects of the jasmine tea odor and (R)-(-)-linalool, one of its major odor components, on autonomic nerve activity and mood states,” Eur. J. Appl. Physiol., vol. 95, no. 2–3, pp. 107–114, Oct. 2005. https://www.ncbi.nlm.nih.gov/pubmed/15976995
doTERRA Arise Chemistry
Goepfert M, Liebl P, Herth N et al. Aroma oil therapy in palliative care: a pilot study with physiological parameters in conscious as well as unconscious patients. J Cancer Res Clin Oncol. (2017) Jun 20. doi: 10.1007/s00432-017-2460-0 https://www.ncbi.nlm.nih.gov/pubmed/28634728
Heuberger E, Hongratanaworakit T, Böhm C, Weber R, Buchbauer G. Effects of chiral fragrances on human autonomic nervous system parameters and self-evaluation. Chem Senses. 2001 Mar;26(3):281-92. https://www.ncbi.nlm.nih.gov/pubmed/11287388
Yang H, Woo J, Pae AN et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539. Epub 2016 Aug 29. https://www.ncbi.nlm.nih.gov/pubmed/27573669
Matsubara E, Fukagawa M, Okamoto T et al. (-)-Bornyl acetate induces autonomic relaxation and reduces arousal level after visual display terminal work without any influences of task performance in low-dose condition. Biomed Res. 2011 Apr;32(2):151-7 https://www.ncbi.nlm.nih.gov/pubmed/21551951
Matsubara E, Fukagawa M, Okamoto T et al. The essential oil of Abies sibirica (Pinaceae) reduces arousal levels after visual display terminal work. Flavour Frag J. 2011;26(3):204-210. https://www.researchgate.net/publication/230089859_The_essential_oil_of_Abies_sibirica_Pinaceae_reduces_arousal_levels_after_visual_display_terminal_work
Guzmán-Gutiérrez SL, Bonilla-Jaime H, Gómez-Cansino R et al. Linalool and β-pinene exert their antidepressant-like activity through the monoaminergic pathway. Life Sci. 2015 May 1;128:24-9. doi: 10.1016/j.lfs.2015.02.021. https://www.ncbi.nlm.nih.gov/pubmed/25771248
Chemistry of Siberian Fir Oil
Boyd EM, Sheppard EP. Nutmeg Oil and Camphene as Inhaled Expectorants. Arch Otolaryngol. 1970;92(4):372-378. doi:10.1001/archotol.1970.04310040060011 https://books.google.com/books?id=rGQps9fQX1YC&pg=PA355&lpg=PA355&dq=Nutmeg+Oil+and+Camphene+as+Inhaled+Expectorants&source=bl&ots=BpYoQFgdia&sig=3dE-NHkfhFmGWbSTNDx_KJi33TA&hl=en&sa=X&ved=0ahUKEwjM2tjs177XAhVFPCYKHWJnA04Q6AEITDAJ#v=onepage&q=Nutmeg%20Oil%20and%20Camphene%20as%20Inhaled%20Expectorants&f=false
Kim SH, Lee SY, Hong CY et al. Whitening and antioxidant activities of bornyl acetate and nezukol fractionated from Cryptomeria japonica essential oil. Int J Cosmet Sci. 2013
Oct;35(5):484-90. doi: 10.1111/ics.12069. Epub 2013 Jul 6. https://www.ncbi.nlm.nih.gov/pubmed/23714012
Yang H, Woo J, Pae AN et al. α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors. Mol Pharmacol. 2016 Nov;90(5):530-539. Epub 2016 Aug 29. https://www.ncbi.nlm.nih.gov/pubmed/27573669
Sleep: Lavender & L-Theanine
Chong Y, Fryar C, Gu Q. Prescription sleep aid use among adults: United States, 2005-2010. NCHS Data Brief. August 2013; 127. Retrieved from: http://www.cdc.gov/nchs/data/databriefs/db127.pdf
Afshar M, et al. Lavender fragrance essential oil and the quality of sleep in postpartum women. Iran Red Crescent Med J. 2015; 17(4):e25880.
Lee S. Effects of aroma inhalation on fatigue and sleep quality of postpartum mothers. Women Heath Nurs. 2004; 10(3):235-243. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443384/
Hirokawa K, Nishimoto T, Taniguchi T. The effects of lavender aroma on sleep quality in healthy Japanese students. Percept Mot Skills. 2012; 114(1):111-122. https://www.ncbi.nlm.nih.gov/pubmed/22582680
Field T, et al. Lavender bath oil reduces stress and crying and enhances sleep in very young infants. Early Human Development. 2008; 84(6):339-401. https://www.ncbi.nlm.nih.gov/pubmed/18053656
Smith A, Halcon L, Savik K, Reis R. Effect of lavender and sleep hygiene on self-reported sleep issues: A randomized controlled trial. J Am Coll Nutri. 2015; 34(5):436-47. https://www.ncbi.nlm.nih.gov/pubmed/26133206
Schuwald A, Noldner M, Wilmes T, Klugbauer N, Leuner K, Muller W. Lavender oil-potent anxiolytic properties via modulation voltage dependent calcium channels. PLoS One. 2013; 8(4):e59998. https://www.ncbi.nlm.nih.gov/pubmed/23637742
Dimpfel W, Pischel I, Lehnfeld R. Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity in volunteers. Eur. J. Med. Res. 2004; 9(9):423-431. https://www.ncbi.nlm.nih.gov/pubmed/15546807
Ghelardini C, Galeotti N, Salvatore G, Mazzanti G. Local anasthetic activity of the essential oil of Lavandula angustifolia. Planta Med.1999; 65(8):700-703. https://www.ncbi.nlm.nih.gov/pubmed/10630108
Barrett J, Tracy D, Giaroli G. To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2013; 23(10):640-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870602/
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Ota M, et al. Effect of L-theanine on glutamatergic functions in patients with schizophrenia. Acta Neuropsychiatr. 2015; 27(5):291-6.
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Lavender Oil and Serotonin
López, V., Nielsen, B., Solas, M., Ramírez, M. J., & Jäger, A. K. (2017). Exploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System Targets. Frontiers in Pharmacology, 8. doi:10.3389/fphar.2017.00280
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